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KMID : 0369819750050030330
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Jorunal of Korean Pharmaceutical Sciences
1975 Volume.5 No. 3 p.330 ~ p.335
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Studies on the Stability of Oxytetracycline - Mg Complex Preparation
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김정우/Kim JW
김광남/김기원/Kim KN/Kim KW
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Abstract
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When the pH of the mixture containing oxytetracycline, $MgCl_26H_2O$ 수식 이미지 (2 : 1) and citric acid in aqueous solution is changed by adding monoethanolamine, some difference substances are produced. In the range of pH 8.5-9.3, the stable substance which exhibit U. V. max. absorption at 267.5-268 nm and 372.5 nm is produced. According to preparing method, the mixture of oxytetracycline. $MgCl_26H_2O$ 수식 이미지 (2 : 1) and citric acid in 75% propylene glycol aqueous solution are dissolved with monoethanolamine, and then, it is standed for a long time. An unknown substance is precipitated. It seems to be a compound containing $MgCl_26H_2O$ 수식 이미지, citric acid and monoethanolamine, but not oxytetracycline.
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